ABSTRACT
Objective To prepare optimization of palonosetron hydrochloride oral disintegrating tablets by orthogonal test. Methods Palonosetron hydrochloride oral disintegrating tablets were prepared with direct compression process.The content of pal-onosetron hydrochloride was determined by HPLC.The formulation was optimized with disintegration time as evaluation indices. Results The optimal formulation(60 mg/tablet)was as follows:L-HPC 12%,mannitol∶SMCC= 2∶1,magnesium stearate 2%, stevia glycosides 3%.The oral disintegrating tablets showed dine appearance and tested better;the disintegration time was 12 sec-onds;the tablets featured a hardness of 3 kg;4 min dissolution rate was 99%.Conclusion The preparation method is simple and reasonable,and the tablets can disintegrate rapidly.
ABSTRACT
Objective: To explore the possibility for detecting tanshinone ⅡA serum level by HPlC chromatograms.Methods: To detect tanshinone ⅡA serum level in 10 healthy subjects by HPLC chromatograms.Results: After take tanshinoneⅡA,they were absorbed quickly and removed rapidly,had significant difference of blood drug level in different subjects.Conclusion: The method is demonstrated to be high sensitive with less disturbance which will provide a new way to perform pharmacokinetic experiment.